At 20H17 Saturday night Netcare 911 responded to reports of a collision on the R28 near West Village in Luipaardsvlei, Krugersdorp, Gauteng.
Reports from the scene indicate that a car and bakkie were involved in a collision resulting in one of the vehicles catching alight.
The Krugersdorp Fire and Rescue Services managed to douse the flames.
Medics assessed the patients and found that an adult male and female had sustained fatal injuries and were sadly declared deceased on the scene.
Another two male patients had sustained serious injuries and once treated were transported by ambulance to hospital for further treatment.