At 06H29 Wednesday morning Netcare 911 responded to reports of a collision on Heidelberg Road in Alberton.
Reports from the scene indicate that the driver of a light motor vehicle lost control resulting in the vehicle rolling down an embankment coming to rest upside down on railway tracks.
Medics assessed the patient an adult female who had sustained serious injuries.
She was treated on scene by Advanced Life support paramedics who activated a Netcare 911 Helicopter ambulance.
Once stabilized the patient was airlifted to a specialist facility for the care she required.